Human LILRB3 ELISA Matched Antibody Pair Set [ABP-Q-04-267] (CAT#: ABP-Q-04-267)

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Human LILRB3 antibody pair set for ELISA use
Capture Antibody: mouse anti-LILRB3 monoclonal antibody
Detection Antibody: rabbit anti-Human LILRB3 polyclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $1,120.00
Antibody Pair Set-Package 2 15 × 96 tests $2,331.43
Datasheet
MSDS
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Lot Number

Antigen Detail
TargetLILRB3
DescriptionLeukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, CD85a and LILRB3, is a single-pass type I membrane protein that belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. LILRB3 / CD85a contains four Ig-like C2-type (immunoglobulin-like) domains. LILRB3 / CD85a contains three copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in the modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. LILRB3 / CD85a is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesMouse
CloneIV01178
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityPolyclonal
Host SpeciesRabbit
ConjugationHRP
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewHuman LILRB3 antibody pair set for ELISA use
Capture Antibody: mouse anti-LILRB3 monoclonal antibody
Detection Antibody: rabbit anti-Human LILRB3 polyclonal antibody conjugated to HRP
SpecificityQuantitative determination of Human LILRB3
Range78.125-5000 pg/ml
Research AreaInnate Immunity
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolLILRB3
Full NameLeukocyte Immunoglobulin Like Receptor B3
BackgroundThis gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative NamesCD85A
Gene ID11025
Uniprot IDO75022

For Research Use Only.

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