Human; Mouse PLK-1 (Thr210) antibody pair set for WB use
Capture Antibody: Mouse Monoclonal IgG1
Detection Antibody: Mouse Monoclonal IgG1
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Antigen Detail | |
|---|---|
| Target | PLK-1 (Thr210) |
| Description | Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene. |
| Species Reactivity | Human; Mouse |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Immunogen | Amino Acid: 300-603 of human PLK-1 |
| Clone | IV0117 |
| Isotype | IgG1 |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD107 |
| Isotype | IgG1 |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.2, containing 0.09% sodium azide |
General Product Property | |
|---|---|
| Product Overview | Human; Mouse PLK-1 (Thr210) antibody pair set for WB use Capture Antibody: Mouse Monoclonal IgG1 Detection Antibody: Mouse Monoclonal IgG1 |
| Specificity | Both the capture and the detection antibodies in this set react with mouse IL-10. |
| Research Area | Inflammation; Immunology |
| Application | WB |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | PLK1 |
| Full Name | Polo-like kinase 1 |
| Background | Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene. |
| Alternative Names | PLK1; PLK; STPK13; polo like kinase 1 |
| Gene ID | 5347 (Human) |
| Uniprot ID | P53350 (Human) |
| GeneCards | PLK1 |
| HGNC | 9077 |
| Ensembl | ENSG00000166851 |
| OMIM | 602098 |
| Involvement in Disease | Diseases associated with PLK1 include Gonococcal Keratitis and Brain Glioma. |
| Function | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. |
| Related Pathways | Its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. |
For Research Use Only.