Human PD-L2 ELISA Matched Antibody Pair Set [ABP-Q-04-301] (CAT#: ABP-Q-04-301)

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Human PD-L2 antibody pair set for ELISA use
Capture Antibody: rabbit anti-Human PD-L2 monoclonal antibody
Detection Antibody: rabbit anti-Human PD-L2 polyclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $919.60
Antibody Pair Set-Package 2 15 × 96 tests $1,919.66
Datasheet
MSDS
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Lot Number

Antigen Detail
TargetPD-L2
DescriptionProgrammed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesRabbit
CloneIV01786
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityPolyclonal
Host SpeciesRabbit
ConjugationHRP
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewHuman PD-L2 antibody pair set for ELISA use
Capture Antibody: rabbit anti-Human PD-L2 monoclonal antibody
Detection Antibody: rabbit anti-Human PD-L2 polyclonal antibody conjugated to HRP
SpecificityQuantitative determination of Human PD-L2
Range25-1600 pg/mL
Research AreaInnate Immunity
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolPDCD1LG2
Full NameProgrammed cell death 1 ligand 2
BackgroundProgrammed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.[4][5] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.[4][6] PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1).
Alternative NamesPDCD1LG2; B7DC; Btdc; CD273; PD-L2; PDCD1L2; PDL2; bA574F11.2; programmed cell death 1 ligand 2
Gene ID80380
Uniprot IDQ9BQ51

For Research Use Only.

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