Human SerpinA3 ELISA Matched Antibody Pair Set [ABP-Q-04-332] (CAT#: ABP-Q-04-332)

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Human SerpinA3 antibody pair set for ELISA use
Capture Antibody: rabbit anti-Human SerpinA3 monoclonal antibody
Detection Antibody: rabbit anti-Human SerpinA3 monoclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $919.60
Antibody Pair Set-Package 2 15 × 96 tests $1,919.66
Datasheet
MSDS
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Lot Number

Antigen Detail
TargetSerpinA3
DescriptionSerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. Besides, ACT gene polymorphism has been implicated with Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesRabbit
CloneIV01343
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityMonoclonal
Host SpeciesRabbit
ConjugationHRP
CloneRD10368
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewHuman SerpinA3 antibody pair set for ELISA use
Capture Antibody: rabbit anti-Human SerpinA3 monoclonal antibody
Detection Antibody: rabbit anti-Human SerpinA3 monoclonal antibody conjugated to HRP
SpecificityQuantitative determination of Human SerpinA3
Range47-3000 pg/mL
Research AreaNeurodegenerative disease
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolSerpinA3
Full NameAlpha 1-antichymotrypsin
Backgroundα1-Antichymotrypsin (symbol α1AC, A1AC or a1ACT) is an alpha globulin glycoprotein and a member of the superfamily of serine protease inhibitors. In humans, it is encoded by the SERPINA3 gene.

α1-Antichymotrypsin can inhibit the activity of certain enzymes called proteases by cutting them into different shapes or conformations, such as cathepsin G found in neutrophils and mast cells Chymase. This activity can protect certain tissues, such as the lower respiratory tract, from damage by proteolytic enzymes.

This protein is produced in the liver and is an acute phase protein induced during inflammation.
Alternative NamesSERPINA3; AACT; ACT; GIG24; GIG25; serpin family A member 3
Gene ID12
Uniprot IDP01011

For Research Use Only.

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