Human TrkC ELISA Matched Antibody Pair Set [ABP-Q-04-292] (CAT#: ABP-Q-04-292)

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Human TrkC antibody pair set for ELISA use
Capture Antibody: Mouse anti-TrkC monoclonal antibody
Detection Antibody: Mouse anti-TrkC monoclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $1,120.00
Antibody Pair Set-Package 2 15 × 96 tests $2,331.43
Datasheet
MSDS
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Lot Number

Antigen Detail
TargetTrkC
DescriptionNT-3 growth factor receptor is also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudate-putamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, The trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signaling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in the TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas, and other cancers.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesMouse
CloneIV01173
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityMonoclonal
Host SpeciesMouse
ConjugationHRP
CloneRD10122
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewHuman TrkC antibody pair set for ELISA use
Capture Antibody: Mouse anti-TrkC monoclonal antibody
Detection Antibody: Mouse anti-TrkC monoclonal antibody conjugated to HRP
SpecificityQuantitative determination of Human TrkC
Range62.5-4000 pg/mL
Research AreaGrowth and Development
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolNTRK3
Full NameNeurotrophic Receptor Tyrosine Kinase 3
BackgroundThis gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Alternative NamesTrkC Tyrosine Kinase; NTRK3
Gene ID4916
Uniprot IDQ16288

For Research Use Only.

Application

AgonistAgonist
AntagonistAntagonist
ApopApoptosis Assay
BlockBlocking
BIBioimaging
ChIPChromatin Immunoprecipitation
Co-IPCo-Immunoprecipitation
CytCytotoxicity Assay
CellActCell Activiation
CellDiffCell Differentiation
DBDot Blot
ECLElectrochemiluminescence
ELISAEnzyme-Linked Immunosorbent Assay
Indirect ELISAIndirect ELISA
Sandwich ELISASandwich ELISA
Competitive ELISACompetitive ELISA
ELISPOTEnzyme-linked Immunosorbent Spot
FuncSFunctional Studies
FACSFluorescence-activated cell sorting
FCFlow Cytometry
FIAFluorescence Immunoassay
FRETFluorescence Resonance Energy Transfer Microscopy
GSGel Shift
HAHemagglutination Assay
HPLCHigh Performance Liquid Chromatography
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IEMImmuno-Electron Microscopy
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
IPImmunoprecipitation
IRMAImmunoradiometric Assay
ISHIn Situ Hybridization
InhibitInhibition Assay
Live-cell imagingLive-cell Imaging Assay
MeDIPMethylated DNA Immunoprecipitation
MAMicroagglutination Assay
MSMass Spectrometry
NeutNeutralization Assay
PepArrPeptide Array
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
RIPRadioimmunoprecipitation
StimStimulation Assay
TCAT-Cell Activation Assay
TRFTime-Resolved Fluorescence
TCTissue Culture
TBTurbidimetry
PBAProtein Binding Assay
PLAProximity Ligation Assay
SDS-PAGESodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis
SPRSurface Plasmon Resonance
WBWestern Blot
CLIAChemiluminescent Immunoassay
CLEIAChemiluminescent Enzyme Immunoassay
ECLIAElectrochemiluminescence Immunoassay
TRFIATime-resolved Fluorescence Immunoassay
LIALaser Immunoassay
MLEIAMicroparticle Luminescence Enzyme Immunoassay
LETIALatex Particle-Enhanced Turbidimetric Immunoassay
LFIALateral Flow Immunoassay
GICAColloidal Gold immunochomatography Assay
ICTImmune Chromatographic Test
LTIALatex Turbidimetric Immunoassay
CMIAChemiluminescence microparticle immuno assay
IACInnuno-Affinity Chromatography
TIATurbidimetric Immunoassay

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