Monkey IL-5 antibody pair set for ELISA useCapture Antibody: Mouse Monoclonal IgG1Detection Antibody: Rat Monoclonal IgG2a
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Antigen Detail | |
|---|---|
| Target | IL-5 |
| Description | Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed.[11] Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. |
| Species Reactivity | Monkey |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Production | Cell culture |
| Clone | IV01924 |
| Isotype | IgG1 |
| Purification | Ion exchange chromatography |
| Buffer | Prior to lyophilization: 0.25 ml PBS containing 125 mM trehalose |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rat |
| Production | Cell culture |
| Conjugation | Biotin |
| Clone | RD10408 |
| Isotype | IgG2a |
| Purification | Affinity chromatography |
| Buffer | Prior to lyophilization: 0.5 ml PBS containing 1% BSA and 125 mM trehalose |
General Product Property | |
|---|---|
| Product Overview | Monkey IL-5 antibody pair set for ELISA use Capture Antibody: Mouse Monoclonal IgG1 Detection Antibody: Rat Monoclonal IgG2a |
| Specificity | Validated for detecting natural rhesus macaque, cynomolgus monkey, pig-tailed macaque, barbary macaque, baboon and African green monkey IL-5. |
| Sensitivity | 0.5 pg/ml |
| Research Area | Inflammation |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | IL5 |
| Full Name | Interleukin 5 |
| Background | Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion - primarily IgA. It is also a key mediator in eosinophil activation. |
| Alternative Names | IL5; EDF; IL-5; TRF; interleukin 5 |
| Gene ID | 3567 |
| Uniprot ID | P05113 |
| GeneCards | IL5 |
| HGNC | 6016 |
| Ensembl | ENSG00000113525 |
| OMIM | 147850 |
| Involvement in Disease | Diseases associated with IL5 include Pulmonary Eosinophilia and Chronic Eosinophilic Pneumonia. |
| Function | Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. |
| Related Pathways | Its related pathways are RET signaling and Signaling by GPCR. |
For Research Use Only.
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