Monkey IP-10 antibody pair set for ELISA useCapture Antibody: Mouse Monoclonal IgG2aDetection Antibody: Mouse Monoclonal IgG2a
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Antigen Detail | |
|---|---|
| Target | IP-10 |
| Description | C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. |
| Species Reactivity | Monkey |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Production | Cell culture |
| Clone | IV01230 |
| Isotype | IgG2a |
| Purification | Cap-Purification |
| Buffer | Prior to lyophilization: 0.25 ml PBS containing 125 mM trehalose |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Production | Cell culture |
| Conjugation | Biotin |
| Clone | RD10500 |
| Isotype | IgG2a |
| Purification | Affinity chromatography |
| Buffer | Prior to lyophilization: 0.5 ml PBS containing 1% BSA and 125 mM trehalose |
General Product Property | |
|---|---|
| Product Overview | Monkey IP-10 antibody pair set for ELISA use Capture Antibody: Mouse Monoclonal IgG2a Detection Antibody: Mouse Monoclonal IgG2a |
| Specificity | Validated for detecting natural rhesus macaque IP-10. |
| Sensitivity | 5 pg/ml |
| Research Area | Immunology; Inflammation |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CXCL10 |
| Full Name | Interferon gamma-induced protein 10 |
| Background | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). |
| Alternative Names | C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; C-X-C Motif Chemokine Ligand 10; Small-Inducible Cytokine B10; C-X-C Motif Chemokine 10 |
| Gene ID | 3627 |
| Uniprot ID | P02778 |
| GeneCards | CXCL10 |
| HGNC | 10637 |
| Ensembl | ENSG00000169245 |
| OMIM | 147310 |
| Involvement in Disease | Diseases associated with CXCL10 include Hepatitis C and Endotheliitis. |
| Function | CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. |
| Related Pathways | Its related pathways are Signaling by GPCR and PEDF Induced Signaling. |
For Research Use Only.
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