Mouse EpCAM ELISA Matched Antibody Pair Set [ABP-Q-04-150]

Type	Size	Price	Quantity
Antibody Pair Set-Package 1	5 × 96 tests	$1,400.00
Antibody Pair Set-Package 2	15 × 96 tests	$2,914.00

Datasheet

MSDS

Certificate of Analysis Lookup

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Lot Number

Antigen Detail
Target	EpCAM
Description	Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â…transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
Species Reactivity	Mouse

Antigen Detail

Target

EpCAM

Description

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â…transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Species Reactivity

Mouse

Capture Antibody
Capture Clonality	Monoclonal
Host Species	Rabbit
Clone	IV01678
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, pH 7.4
Application	ELISA

Capture Antibody

Capture Clonality

Monoclonal

Host Species

Rabbit

Clone

IV01678

Purification

Affinity Chromatography

Buffer

Prior to lyophilization: PBS, pH 7.4

Application

ELISA

Detection Antibody
Det-Clonality	Monoclonal
Host Species	Rabbit
Conjugation	HRP
Clone	RD10269
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, containing 50 % HRP-Protector

Detection Antibody

Det-Clonality

Monoclonal

Host Species

Rabbit

Conjugation

HRP

Clone

RD10269

Purification

Affinity Chromatography

Buffer

Prior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product Overview	Mouse IL2RG antibody pair set for ELISA use Capture Antibody: rabbit anti-EpCAM monoclonal antibody Detection Antibody: rabbit anti-EpCAM monoclonal antibody conjugated to HRP
Specificity	Quantitative determination of mouse EpCAM
Range	78.13-5000 pg/mL
Research Area	Cell Markers
Application	ELISA
Application Notes	Optimal dilutions should be determined experimentally by the user.
Form	Lyophilized
Storage	Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size	1 Set
Sample Type	Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage Statement	Available for Research Use Only. Not for use in therapeutic or diagnostic applications.

General Product Property

Product Overview

Mouse IL2RG antibody pair set for ELISA use
Capture Antibody: rabbit anti-EpCAM monoclonal antibody
Detection Antibody: rabbit anti-EpCAM monoclonal antibody conjugated to HRP

Specificity

Quantitative determination of mouse EpCAM

Range

78.13-5000 pg/mL

Research Area

Cell Markers

Application

ELISA

Application Notes

Optimal dilutions should be determined experimentally by the user.

Form

Lyophilized

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.

Size

1 Set

Sample Type

Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates

Usage Statement

Available for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene Symbol	EpCAM
Full Name	Epithelial cell adhesion molecule
Background	Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia.[5] EpCAM is also involved in cell signaling,[6] migration,[7] proliferation, and differentiation.[8] Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E.[9] Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.
Alternative Names	EPCAM; DIAR5; EGP-2; EGP314; EGP40; ESA; HNPCC8; KS1/4; KSA; M4S1; MIC18; MK-1; TACSTD1; TROP1; epithelial cell adhesion molecule
Gene ID	4072
Uniprot ID	P16422

Target Overview

Gene Symbol

EpCAM

Full Name

Epithelial cell adhesion molecule

Background

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia.[5] EpCAM is also involved in cell signaling,[6] migration,[7] proliferation, and differentiation.[8] Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E.[9] Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.

Alternative Names

EPCAM; DIAR5; EGP-2; EGP314; EGP40; ESA; HNPCC8; KS1/4; KSA; M4S1; MIC18; MK-1; TACSTD1; TROP1; epithelial cell adhesion molecule

Gene ID

4072

Uniprot ID

P16422

Mouse EpCAM ELISA Matched Antibody Pair Set [ABP-Q-04-150] (CAT#: ABP-Q-04-150)

Antigen Detail

Capture Antibody

Detection Antibody

General Product Property

Target Overview