Mouse EphA2 antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | EphA2 |
| Description | EPH receptor A2 (ephrin A receptor 2) is a protein encoded by the EPHA2 gene in humans. This gene belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors are involved in mediating developmental events, especially in the nervous system. The receptors in the EPH subfamily usually have a single kinase domain and an extracellular region, which contains a Cys-rich domain and two fibronectin type III repeats. ephrin receptors are divided into two categories based on the similarity of their extracellular domain sequences and their affinity for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligand. |
| Species Reactivity | Mouse |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01312 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD10112 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Mouse EphA2 antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Mouse EphA2 . |
| Research Area | Cardiovascular; Signal Transduction; Cancer |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EPHA2 |
| Full Name | EPH receptor A2 (ephrin type-A receptor 2) |
| Background | EPH receptor A2 (ephrin A receptor 2) is a protein encoded by the EPHA2 gene in humans. This gene belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors are involved in mediating developmental events, especially in the nervous system. The receptors in the EPH subfamily usually have a single kinase domain and an extracellular region, which contains a Cys-rich domain and two fibronectin type III repeats. ephrin receptors are divided into two categories based on the similarity of their extracellular domain sequences and their affinity for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligand. |
| Alternative Names | EPHA2; Epha2; AW545284; Eck; Myk2; Sek-2; Sek2; ARCC2; CTPA; CTPP1; CTRCT6; EPH receptor A2; ECK |
| GeneCards | EPHA2 |
| HGNC | 3386 |
| Ensembl | ENSG00000142627 |
| OMIM | 176946 |
| Involvement in Disease | Diseases associated with EPHA2 include Cataract 6, Multiple Types and Early-Onset Posterior Subcapsular Cataract. |
| Function | Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a p53/TP53-independent, caspase-8-dependent manner. |
For Research Use Only.
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