Mouse IGFBP2 antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Biotin-Rabbit Monoclonal IgG
Specific Inquiry(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Antigen Detail | |
|---|---|
| Target | IGFBP2 |
| Description | The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. |
| Species Reactivity | Mouse |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01625 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Immunogen | Recombinant Mouse IGFBP2 Protein. |
| Conjugation | Biotin |
| Clone | RD107 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Mouse IGFBP2 antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Biotin-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Mouse IGFBP2 . |
| Sensitivity | 38.3 pg/mL |
| Range | 93.75 pg/mL-6000 pg/mL |
| Research Area | Cardiovascular; Immunology; Signal Transduction |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | IGFBP2 |
| Full Name | insulin-like growth factor binding protein 2, 36kDa |
| Background | The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. |
| Alternative Names | IBP-2; IBP2; Insulin-like growth factor-binding protein 2; IGFBP-2; IGF-BP53; IGF-binding protein 2 |
| HGNC | 5471 |
| Ensembl | ENSG00000115457 |
| OMIM | 146731 |
| Involvement in Disease | Diseases associated with IGFBP2 include Malignant Ovarian Cyst and Insulin-Like Growth Factor I. |
| Function | Inhibit igf-mediated growth and development rate. IGF binding protein can prolong the half-life of IGFs, and has been shown to inhibit or stimulate the growth-promoting effect of IGFs in cell culture. They change the interaction of IGFs with cell surface receptors. |
| Related Pathways | Its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers and Myometrial Relaxation and Contraction Pathways. |
For Research Use Only.
Related products
