Mouse IL-2 antibody pair set for ELISA useCapture Antibody: Rat Monoclonal IgG2aDetection Antibody: Rat Monoclonal IgG2b
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Antigen Detail | |
|---|---|
| Target | IL-2 |
| Description | Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes. The major sources of IL-2 are activated CD4+ T cells and activated CD8+ T cells. |
| Species Reactivity | Mouse |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rat |
| Production | Cell culture |
| Clone | IV01535 |
| Isotype | IgG2a |
| Purification | Affinity chromatography |
| Buffer | Prior to lyophilization: 0.25 ml PBS containing 125 mM trehalose |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rat |
| Production | Cell culture |
| Conjugation | Biotin |
| Clone | RD10247 |
| Isotype | IgG2b |
| Purification | Affinity chromatography |
| Buffer | Prior to lyophilization: 0.5 ml PBS, containing 1% BSA and 125 mM trehalose |
General Product Property | |
|---|---|
| Product Overview | Mouse IL-2 antibody pair set for ELISA use Capture Antibody: Rat Monoclonal IgG2a Detection Antibody: Rat Monoclonal IgG2b |
| Specificity | Validated for detecting natural and recombinant mouse IL-2. |
| Sensitivity | 4 pg/ml |
| Research Area | Inflammation; Immunology |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | IL2 |
| Full Name | Interleukin 2 |
| Background | The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. |
| Alternative Names | Interleukin 2; IL-2; TCGF; T Cell Growth Factor; Interleukin-2 |
| Gene ID | 3558 |
| Uniprot ID | P60568 |
| GeneCards | IL2 |
| HGNC | 6001 |
| Ensembl | ENSG00000109471 |
| OMIM | 147680 |
| Involvement in Disease | Diseases associated with IL2 include Capillary Leak Syndrome and Tropical Spastic Paraparesis. |
| Function | Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes. |
| Related Pathways | Its related pathways are RET signaling and Signaling by GPCR. |
For Research Use Only.
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