Mouse IL10RB ELISA Matched Antibody Pair Set [ABP-Q-04-203] (CAT#: ABP-Q-04-203)

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Mouse IL10RB antibody pair set for ELISA use
Capture Antibody: rabbit anti-IL10RB monoclonal antibody
Detection Antibody: rabbit anti-IL10RB monoclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $1,120.00
Antibody Pair Set-Package 2 15 × 96 tests $2,331.43
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Lot Number

Antigen Detail

TargetIL10RB
DescriptionInterleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins is required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn's disease and ulcerative colitis phenotypes. Crohn's disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Species ReactivityMouse

Capture Antibody

Capture ClonalityMonoclonal
Host SpeciesRabbit
CloneIV01618
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody

Det-ClonalityMonoclonal
Host SpeciesRabbit
ConjugationHRP
CloneRD10458
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property

Product OverviewMouse IL10RB antibody pair set for ELISA use
Capture Antibody: rabbit anti-IL10RB monoclonal antibody
Detection Antibody: rabbit anti-IL10RB monoclonal antibody conjugated to HRP
SpecificityQuantitative determination of Mouse IL10RB
Range39.06-2500 pg/mL
Research AreaInnate Immunity
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview

Gene SymbolIL10RB
Full NameInterleukin 10 receptor, beta subunit
BackgroundThe protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
Alternative NamesIL10RB; CDW210B; CRF2-4; CRFB4; D21S58; D21S66; IL-10R2; Interleukin 10 receptor; beta subunit; interleukin 10 receptor subunit beta
Gene ID3588
Uniprot IDQ08334

For Research Use Only.

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