Mouse MASP1 antibody pair set for sandwich ELISA use
Capture Antibody: Monoclonal IgG
Detection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | MASP1 |
| Description | Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene. MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 into fragments to form a C3-convertase. |
| Species Reactivity | Mouse |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01174 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD10357 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Mouse MASP1 antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Mouse MASP1. |
| Research Area | Cardiovascular; Signal Transduction; Cancer |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | MASP1 |
| Full Name | Mannan-binding lectin serine protease 1 |
| Background | Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene. MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 into fragments to form a C3-convertase. |
| Alternative Names | MASP1; 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF; mannan binding lectin serine peptidase 1; Mannan-binding lectin serine protease 1 |
| Gene ID | 5648 |
| Uniprot ID | P48740 |
| GeneCards | MASP1 |
| HGNC | 6901 |
| Ensembl | ENSG00000127241 |
| OMIM | 600521 |
| Involvement in Disease | Diseases associated with MASP1 include 3Mc Syndrome 1 and 3Mc Syndrome. |
| Function | Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. |
For Research Use Only.