Mouse Uromodulin antibody pair set for sandwich ELISA use
Capture Antibody: Monoclonal IgG
Detection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | Uromodulin |
| Description | Uromodulin (UMOD), also known as Tamm-Horsfall protein (THP), is a Zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene.[5][6] Uromodulin is the most abundant protein excreted in ordinary urine.[ |
| Species Reactivity | Mouse |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01792 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD1099 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Mouse Uromodulin antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Mouse Uromodulin . |
| Research Area | Cardiovascular; Signal Transduction; Cancer |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | UMOD |
| Full Name | Uromodulin |
| Background | Uromodulin (UMOD), also known as Tamm-Horsfall protein (THP), is a Zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene.[5][6] Uromodulin is the most abundant protein excreted in ordinary urine.[ |
| Alternative Names | UMOD; ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; THGP; THP; uromodulin |
| Gene ID | 7369 |
| Uniprot ID | P07911 |
| GeneCards | UMOD |
| HGNC | 12559 |
| Ensembl | ENSG00000169344 |
| OMIM | 191845 |
| Involvement in Disease | Diseases associated with UMOD include Hyperuricemic Nephropathy, Familial Juvenile, 1 and Glomerulocystic Kidney Disease With Hyperuricemia And Isosthenuria. |
| Function | Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia. |
For Research Use Only.