Endocrine System Disease Model Construction Service for Researching Function of Exosomes

The endocrine system in the human body is mainly composed of endocrine glands and endocrine cells distributed in other organs. It controls and regulates the human body through endocrine special chemical substances. In the human body, the endocrine system cannot secrete normal hormones, or the level of hormone secretion is too high, too low, or even unable to secrete, which will lead to an imbalanced state of hormone levels. Long-term endocrine disorders will lead to the occurrence and development of endocrine system diseases (ESDs). The most common diseases of the endocrine system include diabetes and its various complications. Existing studies have found that exosomes participate in the regulation of the secretion of some hormones and related inflammatory responses in ESDs. However, engineered exosomes that can carry therapeutic molecules are expected to be used in the treatment of ESDs. To realize the therapeutic and diagnostic value of exosomes, the construction of corresponding ESDs animal models is of great significance for the study of its pathogenesis and the screening of new therapeutic drugs. Creative Biolabs has been paying attention to the research progress of exosomes and can provide global customers with a variety of ESD animal models for the in vivo function research of exosomes.

Fig.1 Mesenchymal stem cell-derived exosomes alleviate T2DM by improving the hepatic glucose and lipid metabolism via activating AMPK-dependent autophagy. (He, 2020)

Creative Biolabs Endocrine System Disease Model Library for Exosome Functional Research

We can provide including but not limited to the following ESD animal models for exosome functional research.

ESD Animal Models	Inducer	Induction Mechanism	Applicable Animals	Model Features
Type 1 diabetes animal models	Streptozotocin (STZ)-induced	Large-dose injections of STZ can directly cause extensive destruction of islet β cells, resulting in type I diabetes.	Rat	The modeling success rate is high. This model is suitable for the study of the drug efficacy of type I diabetes.
Type 1 diabetes animal models	NOD mice	NOD mice are inbred mice that spontaneously develop type 1 diabetes.	Mouse	This model has many characteristics similar to human autoimmune diabetes and is currently the most widely used animal model of type 1 diabetes.
Type 1 diabetes animal models	Combined induction of STZ and high-fat diet	Injection of a small amount of STZ only destroys the function of a part of the islet β cells, resulting in the insensitivity of peripheral tissues to insulin. Concomitant feeding with a high-calorie diet can result in the development of type II diabetes in these rats.	Rat	The pathological changes of this model are close to those of human type 2 diabetes.
	KK-Ay mice	KK-Ay mice are obtained through inbreeding and have obvious symptoms of obesity and diabetes.	Mouse	The metabolic abnormalities of this model are close to the early lesions of human type 2 diabetes.
	db/db mice	Due to the defect of the leptin gene, the synthesis and secretion of insulin in db/db mice are inhibited. With increasing age, the mice developed obese type 2 diabetes.	Mouse	The course of diabetes in this mouse is very similar to that of humans, and it is currently the most widely used animal model of type 2 diabetes.
	GK rats	GK rats, obtained by inbreeding selected rats with an upper limit of glucose tolerance, can develop type 2 diabetes at 14-16 weeks.	Rat	The model exhibits metabolic, endocrine, and vascular diseases similar to human diabetes.

Creative Biolabs pays attention to the need for innovation and development in the global pharmaceutical industry and is based on the key links of innovative drug research and development. We are constantly innovating our service platform and improving our effectiveness, and we are always committed to providing a full range of one-stop preclinical research services for all exosome developers, including exosome extraction, exosome identification, exosome engineering, exosome labeling, and in vivo and in vitro verification of exosomes. Please contact us with your ideas. We will provide various effective ESD animal models according to your needs to test the effectiveness of therapeutic exosomes.

Reference

He, Q.; Wang, L.; et al. Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy. Stem Cell Research & Therapy. 2020. 11(1):223.

Plant Exosome Isolation