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Monoclonal Camel Antibody Production

Monoclonal Camel Antibody Production Creative Biolabs provides the unique camel monoclonal antibody production service for our global clients. Based on our extensive experience of antibody development and advanced phage display technology, scientists from Creative Biolabs are able to generate the novel camel antibodies with high affinity and specificity.

Camelid, especially camel and llama, is a kind of novel source for the research and development of antibody. Compared with other species, camelid members are the only mammals who can produce not only the conventional antibodies composed of heavy chains and light chains, but also novel antibodies only with heavy chains. This novel isotype, known as heavy chain antibody now, can bind antigens despite consisting of just two heavy chains. This isotype occupies about 50% of the mature immunoglobulins in camelids. The heavy chain antibody in camelids has similar Fc domain to the conventional antibody with both CH2 and CH3 regions, while the Fab domain lacks CH1 regions and only has variable regions (VH), named VHH domain. Moreover, the CDR3 loop of VHH domain is much longer than the one in conventional antibodies and sometimes stabilized by a disulfide bond, which may contribute to binding in cavities, such as enzyme and receptor clefts. According to these traits, heavy chain antibody has the potential to recognize a broader range of epitopes than regular antibodies, and this is valuable in pharmaceutical research. In addition, the VHH domain can also be developed as single domain antibody with appropriate modification.

At present, Creative Biolabs can generate antigen-specific camel antibodies from immunized camel or llama. By our mature immunization strategy and advanced phage display technology, our scientists are confident in constructing immune camel antibody libraries and screening the libraries to isolate monoclonal camel antibodies with high specificity and affinity. In addition, for those special requirements of producing monoclonal camel antibody with naïve paired heavy- and light-chain, Creative Biolabs can also provide our unique Native™ Antibody Discovery Platform, which based on antigen-specific B lymphocytes cytometry technology, to substitute phage display platform for Native™ Camel Antibody Discovery.

As a long-term expert quite recognized in the field of antibody research and development, Creative Biolabs has generated thousands of different antibodies that tailored to the needs of our global clients. Our most devoted scientists are ambitious to offer our customers high-quality monoclonal antibodies from the most comprehensive species, such as human, rodents, rabbit, chicken, llama, camel, shark and alligator. It is our commitment to offer the best antibody production service with high reliability and efficiency.

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