3D Human Calvarial Osteoblast Spheroid Model Introduction

Creative Biolabs is specializing in culturing 3D biology-based spheroid models. Our techniques in mimicking in vivo microenvironments and in vitro remodeling with 3D spheroids will assist you in a more efficient way of studying applications, including drug screening and tissue engineering.

3D Human Calvarial Osteoblast Spheroid Model

Osteoblasts, the bone-forming cells, play a crucial part in the bone remodeling process by regulating resorption and formation, as well as transducing mechanical stimuli into biochemical signals through multiple mechanoreceptors. The calvaria is the top part of the skull and the upper part of the neurocranium. It covers the cranial cavity containing the brain and forms the main component of the skull roof. The 3D human calvarial osteoblast spheroid model is three-dimensional in vitro culture model that mimics the microenvironment of human bone tissue.

Fig 1. Illustration of bone remodeling process. Fig 1. Bone remodeling cycle and bone degeneration in osteoporosis.¹

Applications of 3D Human Calvarial Osteoblast Spheroid Model

Bone defects caused by disease, surgery, or trauma are a major health problem worldwide. Bone tissue engineering is a raising valid alternative to conventional treatments to restore bone integrity. A calvarial osteoblast spheroid model, which allows cellular communication, can accurately resemble bone remodeling and/or the regeneration process.

Preclinical Studies

Bone Remodeling

Drug Discovery

Why Choose Us?

Creative Biolabs provides a highly professional technical team mastering mature technology in the field of cultivating in vitro cells. Our 3D Human Calvarial Osteoblast Spheroid Model has unique advantages in the following aspects:

Derived from primary human osteoblasts

The cell lines we use are more representative of the in vivo bone microenvironment than immortalized cell lines.

Outperform traditional 2D cell culture

Our culture methods can accurately represent tissue cells in vitro and monitor cell number, proliferation, response to stimuli, differentiation, drug metabolism, protein synthesis, etc.

Advanced technologies

Creative Biolabs has advanced 3D modeling technologies such as 3D bioprinting and microfluidics. Our professional team will choose the best way to generate the spheroids based on different models.

Wide applications

Our spheroid models can be applied in cancer research, stem cell research, drug discovery, and other customized research.

In addition to 3D Human Calvarial Osteoblast Spheroid Models, you may also be interested in:

Related Services

Enriching our comprehensive array of 3D spheroid models, Creative Biolabs extends its offerings to encompass a series of specialized technical services, tailored to cater to the diverse research requirements of our clients. Feel free to contact us to explore the potential of our extensively customizable models and to receive a personalized quote.

Reference

Bicer, M.; et al. Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells. Stem Cell Res Ther. 2021, 12(31). Distributed under Open Access License CC BY 4.0, without modification.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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