Creative Biolabs provides anti-idiotypic antibodies production service detecting TOTAL antibodies. We utilize competitive selection of phage display technique to isolate anti-idiotypic antibodies detecting total antibodies. Specialized selection strategies enable the generation of an antibody that binds to an idiotope outside the antigen binding site of the drug. This antibody is not inhibitory and of drug-specific antibodies offers the assay developer enhanced flexibility and better overall information about the availability and the state of the drug antibody.
Anti-ID antibodies’ properties:
• Not paratope specific
• Not inhibitory
• Detects total antibody (free, partially bound, fully bound)
Fig. 1 Binding mode of anti-idiotypic antibody detecting total antibody. Image shows anti-ID Fab antibody in purple, antigen in red and antibody in orange. (Turner 2014)
Please click here to see more custom Anti-Idiotypic Antibodies Production Services from Creative Biolabs to meet your specific requirements.