This product is a RPMI 1788 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (AAVS1-huIgH296-Cpf1-Nocodazole ) genome editor.
| Host Cell | RPMI 1788 |
| Target | ACE2 |
| Insert Clone | 1G4 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <500 |
| Charge (mv) | <-25 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Lung cancer; Breast cancer |
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