This product is a RPMI 1788 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-SpCas9-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | RPMI 1788 |
| Target | ACTN1 |
| Insert Clone | mAb45a |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-3500 |
| Charge (mv) | −5 to -75 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Renal cancer; Lung cancer; Head and Neck cancer; Urothelial cancer |
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