This product is a RPMI 1788 B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-sgRNA-SpCas9-RS-1 ) genome editor.
| Host Cell | RPMI 1788 |
| Target | AFP |
| Insert Clone | 15B284 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | <-1 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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