This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | AIMP1 |
| Insert Clone | AT6D10 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Thymoquinone |
| Particle Size | 1-100 |
| Charge (mv) | −8 to -55 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colorectal cancer; Prostate cancer; Breast cancer |
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