This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-L755507 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | AIMP1 |
| Insert Clone | BCRYE-0125 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | 10 to 45 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Colorectal cancer; Prostate cancer; Breast cancer |
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