This product is a SU-DHL-6 B cell engineering tool based on the Sphingosomes (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-huIgH296-NLS-Cas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | SU-DHL-6 |
| Target | ALPP |
| Insert Clone | 1H2 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | NLS-Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Sphingosomes |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | ≤50 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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