This product is a Raji-Luc2 B cell engineering tool based on the Microbubbles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-317-crispr RNA-SpCas9-RS-1 ) genome editor.
| Host Cell | Raji-Luc2 |
| Target | ALPP |
| Insert Clone | BCACN-020 |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Microbubbles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤10000 |
| Charge (mv) | −25 to -125 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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