This product is a SU-DHL-6 B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-huIgH296-NLS-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | SU-DHL-6 |
| Target | APOBEC3B |
| Insert Clone | 52I71LQ-87-71LT |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | NLS-Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Celastrol |
| Particle Size | 41-3500 |
| Charge (mv) | 6 to 92 |
| Total Atom Count | -61000000 |
| Surface Atoms (%) | -0.7 |
| Specific Surface Area (m2/g) | -3.6 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Breast cancer; Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
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