This product is a Raji B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (CCR5-SpCas9-SpCas9-Brefeldin A) genome editor.
| Host Cell | Raji |
| Target | APOBEC3B |
| Insert Clone | BGA77 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-3 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 22-2410 |
| Charge (mv) | < 1 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
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