This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-289-huIgH296-Cas9-L755507 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | AXL |
| Insert Clone | XR10 |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-4 |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Regorafenib |
| Particle Size | 10-1000 |
| Charge (mv) | <-25 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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