This product is a CA46 B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (CCR5-sgRNA-Cpf1-Brefeldin A) genome editor.
| Host Cell | CA46 |
| Target | BACE1 |
| Insert Clone | BG-18B |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <500 |
| Charge (mv) | -25 to -125 |
| Total Atom Count | -22000000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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