This product is a Ramos (RA 1) B cell engineering tool based on the Magnetic nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-289-huIgH296-Cas12-Nocodazole) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | BACE1 |
| Insert Clone | BG-20B |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-2 |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | ≤10000 |
| Charge (mv) | -31 to -200 |
| Total Atom Count | -22000000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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