This product is a SU-DHL-8 B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-289-crRNA:tracrRNA duplex-SpCas9-Nocodazole ) genome editor.
| Host Cell | SU-DHL-8 |
| Target | BCMA |
| Insert Clone | 6D163 |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | SpCas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-1000 |
| Charge (mv) | 10 to 45 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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