This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (CCR5-huIgH296-SpCas9-Brefeldin A ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | BCMA |
| Insert Clone | BCMA-50 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Mouse genome E-3 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1000 |
| Charge (mv) | <-1 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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