This product is a BC-1 B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (huROSA-26-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | BC-1 |
| Target | BCMA |
| Insert Clone | BG-23B |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-5 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | ESC8 |
| Particle Size | <2300 |
| Charge (mv) | 13 to 67 |
| Total Atom Count | -64000000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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