This product is a HS-Sultan B cell engineering tool based on the Dendrimers (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cas9-Nocodazole ) genome editor.
| Host Cell | HS-Sultan |
| Target | BCMA |
| Insert Clone | MM5356-3F44 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Dendrimers |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | DOX |
| Particle Size | 10-500 |
| Charge (mv) | <80 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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