This product is a Raji B cell engineering tool based on the Gold nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (hROSA26-SpCas9-SpCas9-Brefeldin A ) genome editor.
| Host Cell | Raji |
| Target | BCMA |
| Insert Clone | BCR-YF011 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-8 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤10000 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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