This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (Mannose/Mannose receptor) delivery system and CRISPR-based (huROSA-26-sgRNA-SpCas9-SCR7 pyrazine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | BST2 |
| Insert Clone | BG-28B |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | sgRNA |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Dendrimers |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-500 |
| Charge (mv) | 15-60 |
| Total Atom Count | -22000000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Non-small cell lung cancer; Prostate cancer; Liver cancer |
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