This product is a GA-10 (Clone 4) B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-RS-1) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | BST2 |
| Insert Clone | BG-29B |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Regorafenib |
| Particle Size | 1-100 |
| Charge (mv) | < 0.5 |
| Total Atom Count | -22000000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Non-small cell lung cancer; Prostate cancer; Liver cancer |
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