This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (huROSA-26-crRNA:tracrRNA duplex-Cas12-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | BST2 |
| Insert Clone | BG-30B |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | DOX |
| Particle Size | ≤10000 |
| Charge (mv) | <-25 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Non-small cell lung cancer; Prostate cancer; Liver cancer |
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