This product is a BC-1 B cell engineering tool based on the Nanoparticles (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (SHS-323-crRNA:tracrRNA duplex-Cas12-SCR7 pyrazine) genome editor.
| Host Cell | BC-1 |
| Target | CCL2 |
| Insert Clone | BG-59E |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | ESC8 |
| Particle Size | <2300 |
| Charge (mv) | 10 to 55 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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