This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCL2 |
| Insert Clone | R6R24 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-8 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤10000 |
| Charge (mv) | <-25 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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