This product is a SKO-007 B cell engineering tool based on the Gold nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (huROSA-26-SpCas9-NLS-Cas9-Brefeldin A) genome editor.
| Host Cell | SKO-007 |
| Target | CCL2 |
| Insert Clone | BG-63E |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-8 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 10-1000 |
| Charge (mv) | 10 to 35 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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