This product is a Ramos (RA 1) B cell engineering tool based on the Quantum dots (MUC1 aptamer/MUC1) delivery system and CRISPR-based (huROSA-26-tracr RNA-Cas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCL2 |
| Insert Clone | BG-66E |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Quantum dots |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | DOX |
| Particle Size | ≤10000 |
| Charge (mv) | < 0.5 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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