This product is a Farage B cell engineering tool based on the Sphingosomes (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (CCR5-sgRNA-Cpf1-Brefeldin A ) genome editor.
| Host Cell | Farage |
| Target | CCL2 |
| Insert Clone | R6R39 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Sphingosomes |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | <2500 |
| Charge (mv) | −5 to -40 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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