This product is a Raji B cell engineering tool based on the Magnetic nanoparticles (LRP-1 targetingpeptide/Lipoproteinreceptor-related protein-1) delivery system and CRISPR-based (SHS-291-crRNA:tracrRNA duplex-Cas12-RS-1 ) genome editor.
| Host Cell | Raji |
| Target | CCNB1 |
| Insert Clone | C2-F2 |
| Safe Harbor Sites (SHS) | SHS-291 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-50 |
| Charge (mv) | 10 to 100 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Acute-myeloid-leukemia |
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