This product is a Jiyoye [Jijoye, P-2003, P-3J] B cell engineering tool based on the Sphingosomes (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (hROSA26-sgRNA-Cas9-L755507 ) genome editor.
| Host Cell | Jiyoye [Jijoye, P-2003, P-3J] |
| Target | CCNB1 |
| Insert Clone | 0.T.183 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Sphingosomes |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | <2500 |
| Charge (mv) | 10 to 45 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Acute-myeloid-leukemia |
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