This product is a Ramos (RA 1) B cell engineering tool based on the Microbubbles (Anisamide/ Sigma receptors) delivery system and CRISPR-based (AAVS1-huIgH296-NLS-Cas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCNB1 |
| Insert Clone | RBT-B1 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Microbubbles |
| Ligand/Receptor | Anisamide/ Sigma receptors |
| Active Agents | Thymoquinone |
| Particle Size | 10-50 |
| Charge (mv) | −18 to -84 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Acute-myeloid-leukemia |
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