This product is a Raji B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-huIgH296-SpCas9-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | Raji |
| Target | CCR2 |
| Insert Clone | 1J13 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-3500 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colorectal cancer; Lung cancer |
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