This product is a CA46 B cell engineering tool based on the Magnetic nanoparticles (LRP-1 targetingpeptide/Lipoproteinreceptor-related protein-1) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-Cas12-L755507 ) genome editor.
| Host Cell | CA46 |
| Target | CD163 |
| Insert Clone | BCXC-0805 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <500 |
| Charge (mv) | −18 to -84 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
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