This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-tracr RNA-SpCas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD163 |
| Insert Clone | BCRYC-1122 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Dendrimers |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-500 |
| Charge (mv) | ≤50 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.