This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD24 |
| Insert Clone | SN3A5-2H10 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | DOX |
| Particle Size | <100 |
| Charge (mv) | ≤50 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Esophageal squamous cell carcinoma; Bladder cancer |
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